产品货号：
Z27945
中文名称：
TAF4抗体
英文名称：
Anti-TAF4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TAF4 Antibody |
| 指标别名 | TAF4;TAF2C;TAF2C1;TAF4A;TAFII130;TAFII135;Transcription initiation factor TFIID subunit 4;RNA polymerase II TBP-associated factor subunit C;TBP-associated factor 4;Transcription initiation factor TFIID 130kDa subunit;TAF(II130;TAFII-130;TAFII130;Transcription initiation factor TFIID 135kDa subunit;TAF(II135;TAFII-135;TAFII135 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | TAF4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human TAF4 recombinant protein (Position:D6-K1085). |
| 实际分子量 | 135KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Transcription initiation factor TFIID subunit 4 is a protein that in humans is encoded by the TAF4 gene.Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides.The protein that coordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymerase properly,serves as the scaffold for assembly of the remainder of the transcription complex,and acts as a channel for regulatory signals.TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs.TAFs may participate in basal transcription,serve as coactivators,function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.This gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional activation by retinoic acid,thyroid hormone and vitamin D3 receptors.In addition,this subunit interacts with the transcription factor CREB,which has a glutamine-rich activation domain,and binds to other proteins containing glutamine-rich regions.Aberrant binding to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. |
| Uniprot ID | O00268 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | TATA-box binding protein associated factor 4 |
| 蛋白名全称 | Transcription initiation factor TFIID subunit 4 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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